CorLog is the only removable hemodynamic monitor that can continuously measure up to 30 days.

The median indwelling time of pulmonary arterial catheters is 1.9 days. Echocardiography, CT and MRT are point measurements which cannot guide continuous data driven therapy. Only CorLog enables wireless continuous measurement.

2024

Right Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions

CorLog related summary: While PA and RA pressures have long been used as surrogates for RV peak and end-diastolic pressures, respectively, these variables may not always fully represent actual events within the RV. Furthermore, both past and emerging research demonstrate that there is important information in not only the amplitude of RV pressure but also the shape of the pressure waveform. Recent data indicate that combining information derived from RV pressure amplitude and shape with measurements of SV, or even better maximum and minimum volume, may allow for more comprehensive – and potentially continuous – bedside assessment of RV function. This possibility is enhanced by the fact that the use of machine learning models for estimating cardiac function parameters at the bedside is quickly becoming a reality.

Journal: JCVA

DOI: 10.1053/j.jvca.2024.06.022

Type:

Review

–

2024 – CorLog publication

Precision cardiac monitoring: algorithmic real-time assessment of right ventricular function in pulmonary hypertension

CorLog related summary: Drawing from previous work, this algorithm presents a single-beat pressure methodology that streamlines and automates the computation of P_max and ESP. This facilitates the real-time beat-to-beat assessment of these parameters, for example, through an app interface, thereby enabling a continuous online evaluation of RVEF. Notably, despite the algorithm’s streamlined approach, it showed a good level of accuracy when compared with the traditional offline manual sinusoid fitting technique in our comprehensive investigation involving 99 patients.

Journal: ESC HF
DOI: 10.1002/ehf2.14833

Type:

Retrospective/prospective, Single center study

99/5

2024 – CorLog publication

First in human implantation of the CorLog device for postoperative intravascular pressure sensing in left ventricular assist device patients

CorLog related summary: The first-in-human clinical application of permanent wireless pressure monitoring in an LVAD patient has proven the feasibility of the device as well as the safe and continuous detection of hemodynamic parameters. This new technology offers a viable and needed option for wireless, continuous right heart monitoring in heart failure patients for the first 30 days after LVAD implantation.

Journal: Artificial Organs
DOI: 10.1111/aor.14690

Type:

Case report

2023 – CorLog publication

AHA23 - Cardiopulmonary Best Abstract Award: Pausing Reveals Exercise-Induced Uncoupling: Exploring the Dynamics of RV-PA Coupling in the Six-Minute Walking Test

CorLog related summary: This is the first investigation into the significance of RV-PA coupling in real-life exercise limitation and dyspnea during the 6MWT. Pauses observed during the 6MWT can serve as indicators of exercise-induced uncoupling. We used a wireless hemodynamic monitoring system (CorLog, emka-medical, Germany) to continuously measure right ventricular pressure in 10 patients with PH (8 = group I, 1 = III, 1 = IV) during a 6MWT.

Journal: Circulation/AHA23
DOI: 10.1161/circ.148.suppl_1.15449

Type:

Case report

2022 – CorLog publication

Pressure based beat-to-beat right ventricular ejection fraction and Tau from continuous measured ventricular pressures in COVID-19 ARDS patients

CorLog related summary: The continuous long-term registration of right ventricular systolic pressure by an ultrathin probe in patients with PH is for several reasons of special interest: first, transthoracic echocardiography substantially underestimated in 60% of patients with PH the true RVSP and PAP measured by right heart catheterization, and second, a pulmonary artery catheter because of its wide range of complications can be left in place only for few days. Thus, continuous long-term monitoring of RVSP and ePAD is the only way for reliable detection and treatment of right ventricular hypertension, PH and consecutive changes in RVEF.

Journal: Pulmonary Circulation
DOI: 10.1002/pul2.12179

Type:

Retrospective, single center study

2022 – CorLog publication

Monitoring of Right Ventricular Failure with Daily Pressure-Volume Loops Obtained via an App and
Three-Dimensional Echocardiography

CorLog related summary: In our opinion, the described method is an elegant and promising approach for monitoring
RV function and response to treatment by PV loop analysis. PV loops can be created at will
by performing three-dimensional echocardiography, avoiding further invasive procedures for
the patient.

Journal: Circulation: Heart Failure
DOI: 10.1161/CIRCHEARTFAILURE.122.010097

Type:
Case report

N:
1

2022

Elucidating the Clinical Implications and Pathophysiology of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Call to Action

CorLog related summary: PH-HFpEF is a growing epidemic with high morbidity and mortality and no treatment. The clear unmet need and lethal nature of PH-HFpEF must be met with novel solutions at all levels of therapeutic development.

Journal: Circulation

DOI: 10.1161/CIR.0000000000001079

Type:
Science Advisory

N:
–

2022

Exercise testing in heart failure with preserved ejection fraction: an appraisal through diagnosis, pathophysiology and therapy

CorLog related summary: In HFpEF, exercise intolerance is a hallmark manifestation, characterized by impairment in the physiological reserve capacity of multiple organ systems that is the cardiac dynamics itself and/or related comorbid conditions and extracardiac factors. The relative cardiac and extracardiac deficits vary among individuals. Therefore, detailed measurements made during exercise are necessary to identify and rank-order the multiorgan system limitations in exercise reserve capacity.

Journal: European Journal of Heart Failure
DOI: 10.1002/ejhf.2601

Type:
Clinical consensus statement

N:
–

2021 – CorLog publication

Continuous long-term wireless measurement of right ventricular pressures and estimated diastolic pulmonary artery pressure in patients with severe COVID-19 acute respiratory distress syndrome

CorLog related summary: Thus, insertion of an ultrathin probe into the right ventricle seems to be the only way of continuous long-term monitoring of right ventricular and pulmonary artery pressures for reliable detection and treatment of right ventricular hypertension and PAH.

Journal: ESC HF
DOI: 10.1002/ehf2.13600

Type:
Retrospective, single center study

N:
30

2020

Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction

CorLog related summary: RV dysfunction is an independent determinant on survival in patients with all forms of PH.

Journal: Cardiovascular diagnosis and therapy
DOI: 10.21037/cdt-20-479

Type:
Meta analysis

N:
3300

2020

Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality

CorLog related summary: Use of complete PAC-derived hemodynamic data prior to MCS initiation is associated with improved survival from CS.

Journal: JACC – Heart Failure
DOI: 10.1016/j.jchf.2020.08.012

Type:
Retrospective, multicenter

N:
1414

2019

Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment

CorLog related summary: In patients with pulmonary hypertension, the adaptation of the right ventricle to the increase in afterload (RV–arterial coupling) is a key determinant of outcome. […] Given the prognostic relevance of RV–arterial coupling in pulmonary hypertension, simplified methods to assess RV–arterial coupling should be validated and incorporated into routine clinical follow-up and future clinical trials.

Journal: British Journal of Pharmacology
DOI: 10.1111/bph.14866

Type:
Meta analysis

N:
–

2017

Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor

CorLog related summary: Baseline ePAD is a predictor of mortality, independent of other covariates that have previously been demonstrated to predict mortality. Change in ePAD, from baseline to 6 months was associated with changes in subsequent mortality rate; this relationship is durable.

Journal: Circulation – Heart Failure
DOI: 10.1161/CIRCHEARTFAILURE.116.003594

Type:
Prospective, randomized, multicenter

N:
790

2013

Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension

CorLog related summary: Doppler echocardiography allows for accurate measurements of the pulmonary circulation, but with moderate precision, which explains why the procedure is valid for population studies but cannot be used for the individual diagnosis of pulmonary hypertension.

Journal:International Journal of Cardiology
DOI: 10.1016/j.ijcard.2013.07.005

Type:
Prospective, single center study

N:
152

2005

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness

CorLog related summary: Median indwelling time of pulmonary arterial catheters was 1.9 days.

Journal: JAMA
DOI: 10.1001/jama.294.13.1625

Type:
Prospective, randomized, multicenter

N:
433

CorLog is the only removable hemodynamic monitor that can continuously measure up to 30 days.

Right Ventricular Pressure Waveform Analysis – Clinical Relevance and Future Directions

Precision cardiac monitoring: algorithmic real-time assessment of right ventricular function in pulmonary hypertension

First in human implantation of the CorLog device for postoperative intravascular pressure sensing in left ventricular assist device patients

AHA23 - Cardiopulmonary Best Abstract Award: Pausing Reveals Exercise-Induced Uncoupling: Exploring the Dynamics of RV-PA Coupling in the Six-Minute Walking Test

Pressure based beat-to-beat right ventricular ejection fraction and Tau from continuous measured ventricular pressures in COVID-19 ARDS patients

Monitoring of Right Ventricular Failure with Daily Pressure-Volume Loops Obtained via an App and Three-Dimensional Echocardiography

Elucidating the Clinical Implications and Pathophysiology of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Call to Action

Exercise testing in heart failure with preserved ejection fraction: an appraisal through diagnosis, pathophysiology and therapy

Continuous long-term wireless measurement of right ventricular pressures and estimated diastolic pulmonary artery pressure in patients with severe COVID-19 acute respiratory distress syndrome

Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction

Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality

Right heart failure in pulmonary hypertension: Diagnosis and new perspectives on vascular and direct right ventricular treatment

Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor

Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension

Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness

Monitoring of Right Ventricular Failure with Daily Pressure-Volume Loops Obtained via an App and
Three-Dimensional Echocardiography